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Anti-MCF2/FITC Conjugated抗體上海鈺博生物科技有限公司

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產品名稱: Anti-MCF2/FITC Conjugated抗體
英文名稱: Anti-MCF2/FITC
抗體貨號: YB--18722R-FITC
產品規格: 20ul/50ul/100ul/200ul
級    別: , 分析純, 見說明書
產品產地: 中國/美國
品牌商標: Ybscience
價    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human MCF2
抗原來源: Rabbit
抗體來源: Rabbit
適用物種: Human,
見說明書conjugate:見說明書
Isotype:見說明書
應用范圍: 科研使用
更新時間: 2020/7/9 12:59:00
詳細資料:  實驗方法技術資料
瀏覽人數:1191
誠信指數:10146點
了解更多:進入公司展臺
使用范圍:僅限科研使用,不能應用于臨床
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產品詳細描述

 Anti-MCF2/FITC Conjugated抗體

產品編號 YB-18722R-FITC
英文名稱 Anti-MCF2/FITC
中文名稱 FITC標記的MCF2蛋白抗體
別    名 DBL; DBL-transforming protein; MCF2; MCF2_HUMAN; MCF2-transforming protein; Proto-oncogene DBL; Proto-oncogene MCF-2.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  信號轉導  G蛋白偶聯受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, 
產品應用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 108kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MCF2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.[provided by RefSeq, Jan 2010]

Function:
Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.

Subunit:
Interacts with an array of inositol phospholipids such as phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P). May interact with CCPG1. 

Subcellular Location:
Cytoplasm Isoform 1: Membrane Isoform 3: Membrane. Note: Colocalizes with CDC42 to plasma membrane.

Tissue Specificity:
Isoform 1 is expressed only in brain. Isoform 3 is expressed in heart, kidney, spleen, liver and testis. Isoform 4 is expressed in brain, heart, kidney, testis, placenta, stomach and peripheral blood. The protein is detectable in brain, heart, kidney, intestine, muscle, lung and testis.

Post-translational modifications:
Phosphorylation by TNK2 enhances guanine nucleotide exchange factor (GEF) activity toward Rho family proteins.

DISEASE:
MCF2 and DBL represent two activated versions of the same proto-oncogene.

Similarity:
Belongs to the MCF2 family.
Contains 1 CRAL-TRIO domain.
Contains 1 DH (DBL-homology) domain.
Contains 1 PH domain.
Contains 1 spectrin repeat. 

Database links:

Entrez Gene: 4168 Human

Omim: 311030 Human

SwissProt: P10911 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

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